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Literature summary extracted from
- On the mechanism of bile acid inhibition of rat sterol 12alpha-hydroxylase gene (CYP8B1) transcription: roles of alpha-fetoprotein transcription factor and hepatocyte nuclear factor 4alpha (2002), Biochim. Biophys. Acta, 1583, 63-73.
Natural Substrates/ Products (Substrates)
| EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 1.14.14.139 | additional information | Rattus norvegicus | key enzyme of the bile acid biosynthetic pathway. It regulates the composition of bile acids in bile, i.e. ratio between cholic acid and chenodeoxycholic acid. Bile acids inhibit CYP8B1 gene transcription by inducing alpha-fetoprotein transcription factor and inhibiting HNF4alpha expression | ? | - |
? |  |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 1.14.14.139 | Rattus norvegicus | - |
- |
- |
Source Tissue
| EC Number | Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|---|
| 1.14.14.139 | liver | - |
Rattus norvegicus | - |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 1.14.14.139 | additional information | key enzyme of the bile acid biosynthetic pathway. It regulates the composition of bile acids in bile, i.e. ratio between cholic acid and chenodeoxycholic acid. Bile acids inhibit CYP8B1 gene transcription by inducing alpha-fetoprotein transcription factor and inhibiting HNF4alpha expression | Rattus norvegicus | ? | - |
? | |
Synonyms
| EC Number | Synonyms | Comment | Organism |
|---|---|---|---|
| 1.14.14.139 | 12alpha-hydroxylase gene | - |
Rattus norvegicus |
| 1.14.14.139 | CYP8B1 | - |
Rattus norvegicus |
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Release 2023.1 (January 2023)
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